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In 1985, the National Ambulatory Medical Care Survey counted 525,000 doctor-office visits for erectile dysfunction.

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When treated with sildenafil, the rats released threefold as much oxytocin compared with those who received no drug. The concomitant use of potent cytochrome P450 3A4 inhibitors eg, erythromycin, ketoconazole, itraconazole as well as the nonspecific CYP inhibitor, cimetidine, is associated with increased plasma levels of sildenafil see DOSAGE AND ADMINISTRATION.
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